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The instrumentation for gamma-ray astronomy has advanced tremendously during the last two decades. The study of the most violent environments in the Universe has opened a new window to understand the frontier of physics, exploring processes that are beyond the capabilities of Earth-based laboratories to replicate. In this talk I will review the different strategies and instrumentation for gamma-ray astronomy, and report some of the most exciting observations from this rapidly evolving field. Among all instruments, the talk will be somewhat biased towards scientific results obtained with MAGIC, which is located on the Canary Island of La Palma, and has been at the forefront of gamma-ray astronomy since 2003, participating in multiple multiwavelength and multimessenger observational campaigns.